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Tuesday, April 16, 2024

IUI: An Increasing Success Rate To Fertilization


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In an era dominated by the human population, the demographic data after every census allocates the problems and risks involved in pregnancy. This, in part, analyzes the growth and fall of population density per se and records the pregnancy methods people adopt. Intrauterine insemination (IUI), an efficient, non-invasive procedure of fertilization is being adopted by many couples trying to conceive. The increase in better methods and more scientific approaches to insemination is increasing the IUI success symptoms day by day

What is the procedure of IUI?

In intrauterine insemination, the sperm from the donor are cleansed in a special way. A thin tube called the speculum linking the woman’s uterus allows them to flow directly into the uterus. This process increases the proximity between the sperm and the uterus, benefitting the flow. The treatment begins on the first day of the menstrual cycle, that is, on the first day of the month. In the course of the treatment, the woman undergoes ultrasonography and her menstrual cycle is trailed for about 12-14 days for the egg to reach the ovulation stage. 

How is the success rate of IUI increasing?

With the advancement in technology and the prevailing comparison between IUI and IVI(in-vitro fertilization), newer methods are being considered to facilitate the fertility success of the uterus. In the case of the male sperm, care is taken to determine the nature of those from the semen. Sperm concentration can be inferred with the help of a hemocytometer chamber, a photometer or a microscale. In the case of the ovary acting as the recipient, clomiphene citrate or gonadotropins as fertility medications may be considered to enhance the process and improve the egg’s quality. Through a thorough diagnosis from a healthcare provider, vis a vis a doctor in charge of the treatment, the woman is given scheduled appointments to abide by to increase the chances of success.

Factors affecting the success rate of IUI

  • Sperm health quality: The donor’s sperm, which is prescribed to be injected into a certain uterus, undergoes a cleaning procedure before it becomes ready for insemination. The donor’s health affects the concentration of sperm in the semen. One must quit smoking for a month before being ready to donate, avoid contacting heat in the scrotum, and ejaculate regularly to ensure sperm health. Either fresh sperm or frozen can be used, as recommended by the doctor.
  • Age: The woman’s age contributes to the success rate of fertilization through IUI. It is generally higher(around 30%) in the females’ uterus aged below 24 years. As the age gap increases by 5 or 8, the percentage falls, narrowing to 3.2% or 4% for those above 40. 
  • Follicles: The average antral follicle count in the ovary, ranging from 6 to 10, is normal. A lower number would fall below six, and a higher concentration would exceed 12. Follicles need a diametric range of 18-24 mm to be ready for the egg collection. A denser concentration of follicles increases the success rate of pregnancy. 
  • Drug Type: Recent research shows that gonadotropins work more efficiently than clomiphene citrate in aiding in the process of successful fertilization. Letrozole(Femara) or Clomid could also be used to boost the chances of fertilization, sometimes, even on the first try, increasing the possibility to about 30%. Moreover, the medical professional in charge of the diagnosis adheres to the process with a strict routine that must be followed according to his/her expertise for desired outcomes.  

Why should IUI be considered more efficient than IVF?

In IVF(in-vitro fertilization), the ovarian eggs are surgically removed with a needle that goes through the vagina to the uterus. In contrast, in IUI, the sperms are injected into the ovary through a speculum. IVF is a costly and more invasive process, whereas IUI is cheaper, costing around 10,000-50,000 INR around the country and also less invasive, with less time consumption. Even though chances seem lower in cases of IUI, there are ways in which the process can be sped up with the help of medication from doctors and healthcare professionals. There are even times when a success rate of IUI can lead to multiple pregnancies when the ovarian stimulation is greater than usual. 

IUI centers and facilities and their treatment cost

The facilities and centers of IUI that operate in India are located in almost all the major states. It is a pretty affordable treatment that is varied by the situation of the ovary and sperm, and the ovary is diagnosed to check if it is fit for fertilization. Sometimes, attaining pregnancy on the first try is tough, so the cycle is repeated. The average success rate of IUI in pregnancy in India is generally obtained after the third cycle. The cost of the treatment depends upon the number of cycles one needs to undergo until the desired pregnancy. Many states in India, like Hyderabad, Raipur, Indore, Nagpur, Visakhapatnam and others, have centers for IUI treatment. Recently, one IUI centre in Delhi has been established. The process of intrauterine insemination is gaining ground among couples and surrogates as a very beneficial and effective approach to pregnancy. Newer advents to this treatment have also increased the success rates way higher than they previously were.   

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